Title: Cayos Zapatilla Vacation Packages 2026 from $562 | Expedia.com

[Cayos Zapatilla Travel Guide](https://expedia.com/Cayos-Zapatilla.dx6286134)[Hotels in Cayos Zapatilla](https://expedia.com/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[Vacation Rentals in Cayos Zapatilla](https://expedia.com/Cayos-Zapatilla-Vacation-Rentals.d6286134.Travel-Guide-VacationRentals)[Flights to Cayos Zapatilla](https://expedia.com/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[Car Rentals in Cayos Zapatilla](https://expedia.com/Car-Rentals-In-Cayos-Zapatilla.d6286134.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6286134/443bad9e-c57b-4b6d-aec8-29e5bf3e9898.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Cayos Zapatilla Vacations from $562

## Book a Hotel + Flight or Car together to unlock savings

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## The Latest Cayos Zapatilla vacation packages

Price found within the past 48 hours. Click for updated prices.

![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Villa Botero By Casa Mojito B&B

$562

per person

Apr 1 - Apr 5

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Mahogany Suites

$686

per person

Apr 29 - May 5

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

10/10 Exceptional! (1 review)

Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,197

per person

Apr 29 - May 5

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

Breakfast is continental buffet and AMAZING. The fruit, the many options, the omelettes, truly delicious. The room was spotless, the location more than convenient to walk and explore Casco Viejo, the staff was very kind and helpful. The only downside is that the room we needed (family) was ready a bit after check in time (3:20 pm instead of 3 pm). I would stay again here.

Reviewed on Feb 23, 2026

![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Riu Plaza Panama

Bella Vista

$844

per person

Apr 29 - May 5

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (4,515 reviews)

The service at the pool was less than sub-par. No service at the table. Even at the bar, I had to give my order to 3 people. The first person gave me part of the order. The second person disappeared. It took more than 25 mins to get two drinks.

Reviewed on Feb 23, 2026

![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Megapolis Hotel Panamá

San Francisco

$1,078

per person

May 8 - May 13

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,204 reviews)

clean room, friendly staff, reasonably priced

Reviewed on Feb 20, 2026

Don't see what you're looking for?

See all available trips from Columbus to Cayos Zapatilla

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-23/2026-03-30/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6286134)

## Cayos Zapatilla Hotel Deals

![Tropical Suites Hotel](https://images.trvl-media.com/lodging/4000000/3610000/3608200/3608197/0dde6095_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Tropical Suites Hotel

First Street, Bocas Town Bocas del Toro 

Fully refundableReserve now, pay when you stay

$182 nightly

$200 total

Mar 23 - Mar 24

Total with taxes and fees

9.2/10 Wonderful! (302 reviews)

Beautiful pool. Room was clean and bathroom was spacious. Restaurant menu was healthy options and nice cocktails. Service was sometimes slow but overall the experience was good

Reviewed on Feb 21, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=3608197&PinnedHotelID=3608197&HadPinnedHotel=true&regionId=6286134)

![Cosmic Crab Resort](https://images.trvl-media.com/lodging/19000000/18920000/18918800/18918788/699d1e4d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Cosmic Crab Resort

Carenero Island Trail Bocas del Toro Bocas del Toro

$68 nightly

$76 total

Mar 3 - Mar 4

Total with taxes and fees

8/10 Very Good! (130 reviews)

Room was in fairly good condition. Staff did not appear to be happy!

Reviewed on Feb 18, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=18918788&PinnedHotelID=18918788&HadPinnedHotel=true&regionId=6286134)

![Bocas Paradise Hotel](https://images.trvl-media.com/lodging/9000000/8130000/8124800/8124781/f0ebf030_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Bocas Paradise Hotel

Bocas Town Bocas del Toro 

Fully refundableReserve now, pay when you stay

$88 nightly

$97 total

Mar 5 - Mar 6

Total with taxes and fees

8.8/10 Excellent! (127 reviews)

to much noise!!

Reviewed on Feb 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&selected=8124781&PinnedHotelID=8124781&HadPinnedHotel=true&regionId=6286134)

[See all 302 properties in Cayos Zapatilla](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F24%2F2026&endDate=2%2F25%2F2026&regionId=6286134)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Cayos Zapatilla Vacation Packages

## Cayos Zapatilla Essential Information

| Language        | Spanish                     |
| --------------- | --------------------------- |
| Currency        | Panamanian balboas          |
| Local Welcome   | ¡Hola!                      |
| Local Goodbye   | Adiós                       |
| Closest Airport | Tocumen Intl. Airport (PTY) |

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- [Isla Bastimentos Vacation Rentals ](https://www.expedia.com/Isla-Bastimentos-Vacation-Rentals.d6238840.Travel-Guide-VacationRentals)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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